PRODUCTS Cadenza C18 Columns Cadenza CW-C18
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IMTAKT HPLC COLUMN Cadenza CW-C18

Wide Pore ODS Column

IMTAKT HPLC COLUMN Cadenza CW-C18

FEATURES

Wide pore (30nm) silica ODS column

Unique polymeric end-capping

Analysis of antibiotics, basic compounds, phospholipids, and ceramides

Separation of slightly larger compounds

High-throughput separation

Wide range of column sizes: Inner diameter 0.075 - 28mm / Length 10-500mm

MAIN SPECIFICATIONS

Particle size: 3μm (Cadenza CW-C18),
5μm (Cadenza 5CW-C18)
Base materials: Fully porous, high-purity silica gel
Pore size: 30nm
Ligand: Octadecyl group
End-capping: Present (polymeric end-capping)
Target molecular weight: Below 30kDa
pH range: pH 1.5-9
Maximum pressure: 250bar / 3,500psi / 25MPa
USP Code: L1

In recent years, pharmaceuticals have shown a tendency toward increasingly complex molecular structures, with some molecules exceeding 1000 Da. As a result, there are concerns that they may have difficulty penetrating the narrow pores (10-15nm) of conventional ODS columns, leading to poor peak shapes. This issue arises from the uneven diffusion of substances within the pores and the difficulty in end-capping smaller pore sizes, which increases the influence of residual silanols.

The Cadenza CW-C18 is a high-performance ODS column utilizing wide-pore silica with a pore size of 30nm, employing the same ODS ligand introduction and unique polymeric end-capping process as Cadenza CD-C18. While its specific surface area is one-third that of CD-C18, resulting in shorter retention under the same conditions, its hydrophobic recognition capability (hydrophobic interactions) is equivalent. As a result, it enables faster separations compared to CD-C18 while maintaining good response for large molecules around 500 Da and above. Its ability to facilitate the elution of highly hydrophobic compounds like phospholipids is also a notable feature.

Due to its wide pores, CW-C18 achieves efficient end-capping, promising excellent results in the analysis of basic compounds and antibiotics. Furthermore, CW-C18 is a high-density ODS column that can use 100% aqueous mobile phases, making it useful for analyzing highly polar compounds.

[Latest Applications]

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